In one embodiment, a sender in a shared-communication network determines whether a pending frame is low-latency or high-throughput, and sets a maximum transmission unit (MTU) of the pending frame as a first MTU in response to a low-latency frame and a longer second MTU in response to a high-throughput frame. In another embodiment, a receiver receives a data frame from a sender according to an MTU, and determines a trigger for adjusting the MTU based on latency requirements. In response to the trigger, the receiver sets an interrupt flag in a link-layer acknowledgment for the received data frame. In still another embodiment, a sender determines a pending low-latency data frame to send to a receiver operating according to an MTU, and sends a control message to the receiver to indicate the pending low-latency data frame and an adjusted MTU.