发明申请
- 专利标题： FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
- 专利标题（中）： 抗ALPHA4BETA7抗体的配方
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申请号： US14114832申请日： 2012-05-02
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公开(公告)号： US20140377251A1公开(公告)日： 2014-12-25
- 发明人: Willow Diluzio , Nobel T. Truong , Csanad M. Varga , Vaithianathan Palaniappan , Jason Brown , Irving H. Fox , Catherine Scholz
- 申请人： Willow Diluzio , Nobel T. Truong , Csanad M. Varga , Vaithianathan Palaniappan , Jason Brown , Irving H. Fox , Catherine Scholz
- 申请人地址： US MA Cambridge
- 专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2012/036072 WO 20120502
- 主分类号： A61K47/26
- IPC分类号： A61K47/26 ; A61K47/18 ; A61K39/395
摘要：
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 anti body in vivo.
公开/授权文献
- US09764033B2 Formulation for anti-α4β7 antibody 公开/授权日：2017-09-19
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