发明申请
US20140377820A1 MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ISOPROPANOL WITH PRIMARY ALCOHOLS, DIOLS AND ACIDS
审中-公开
用主要醇，二醇和酸共同生产异丙酚的微生物和方法
- 专利标题： MICROORGANISMS AND METHODS FOR THE CO-PRODUCTION OF ISOPROPANOL WITH PRIMARY ALCOHOLS, DIOLS AND ACIDS
- 专利标题（中）： 用主要醇，二醇和酸共同生产异丙酚的微生物和方法
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申请号： US14167693申请日： 2014-01-29
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公开(公告)号： US20140377820A1公开(公告)日： 2014-12-25
- 发明人: Priti PHARKYA , Anthony P. BURGARD , Robin E. OSTERHOUT , Mark J. BURK , Jun SUN
- 申请人： Genomatica, Inc.
- 申请人地址： US CA San Diego
- 专利权人： Genomatica, Inc.
- 当前专利权人： Genomatica, Inc.
- 当前专利权人地址： US CA San Diego
- 主分类号： C12P7/40
- IPC分类号： C12P7/40 ; C12P7/18 ; C12P7/04
摘要：
The invention provides a non-naturally occurring microbial organism having n-propanol and isopropanol pathways, 1,4-butanediol (14-BDO) and isopropanol pathways, 1,3-butanediol (13-BDO) and isopropanol pathways or methylacrylic acid (MAA) and isopropanol pathways. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in each of the respective n-propanol, 14-BDO, 13-BDO or MAA and isopropanol pathways. The invention additionally provides a method for co-producing n-propanol and isopropanol, 14-BDO and isopropanol, 13-BDO and isopropanol or MAA and isopropanol. The method can include culturing an n-propanol and an isopropanol co-producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an n-propanol, an isopropanol, a 14-BDO, a 13-BDO and/or a MAA pathway enzyme in a sufficient amount to produce each of the respective products, under conditions and for a sufficient period of time to produce each of the respective products.
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