发明申请
- 专利标题: Treatment of coagulopathy with hyperfibrinolysis
- 专利标题(中): 用超纤维蛋白溶解治疗凝血病
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申请号: US13704354申请日: 2010-12-15
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公开(公告)号: US20150005238A1公开(公告)日: 2015-01-01
- 发明人: Karl-Uwe Petersen , Michael Ernest Nesheim , Jonathan Herbert Foley
- 申请人: Daniel A. Nesheim
- 申请人地址: DE 52062 Aachen
- 专利权人: Paion Deutschland GmbH
- 当前专利权人: Paion Deutschland GmbH
- 当前专利权人地址: DE 52062 Aachen
- 优先权: EPPCT/EP2010/003541 20100614
- 国际申请: PCT/EP2010/007632 WO 20101215
- 主分类号: C07K14/745
- IPC分类号: C07K14/745 ; G01N33/573
摘要:
The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.
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