Invention Application
US20150011471A1 REGENERATION OF ISLET BETA CELLS BY HSP60 DERIVED PEPTIDES 审中-公开
通过HSP60衍生肽再培养ISLET BETA细胞

  • Patent Title: REGENERATION OF ISLET BETA CELLS BY HSP60 DERIVED PEPTIDES
  • Patent Title (中): 通过HSP60衍生肽再培养ISLET BETA细胞
  • Application No.: US14379772
    Application Date: 2013-02-28
  • Publication No.: US20150011471A1
    Publication Date: 2015-01-08
  • Inventor: Irun R. CohenRaanan Margalit
  • Applicant: Yeda Research and Development Co. Ltd.
  • International Application: PCT/IL2013/050177 WO 20130228
  • Main IPC: A61K38/17
  • IPC: A61K38/17
REGENERATION OF ISLET BETA CELLS BY HSP60 DERIVED PEPTIDES
Abstract:
The present invention provides compositions for use in the treatment of long-established type 1 diabetes (T1D) using peptides and analogs of heat shock protein 60 (Hsp60). The invention is exemplified using DiaPep277, a peptide analog of human Hsp60, which is shown to induce increase in plasma C-peptide and regeneration of islet beta cells. The invention further relates to regimens useful for treatment of long established T1D in patients having no demonstrable islet beta cell-function.
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