发明申请
- 专利标题： LRRK-2-Mediated Neuronal Toxicity
- 专利标题（中）： LRRK-2介导的神经元毒性
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申请号： US13508180申请日： 2010-11-08
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公开(公告)号： US20150018301A1公开(公告)日： 2015-01-15
- 发明人: Byoung Dae Lee , Ted M. Dawson , Valina L. Dawson , Andrew B. West , Howard Federoff
- 申请人： Byoung Dae Lee , Ted M. Dawson , Valina L. Dawson , Andrew B. West , Howard Federoff
- 申请人地址： US MD Baltimore
- 专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： US MD Baltimore
- 国际申请： PCT/US10/55857 WO 20101108
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; A61K31/404 ; A61K31/7064 ; A61K31/122 ; A61K31/416
摘要：
Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration were identified. The presently disclosed subject matter establishes that LRRK2-induced degeneration of neurons in vivo is kinase dependent and that LRRK2 kinase inhibition provides a potential new neuroprotective paradigm for treating Parkinson's disease.
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