发明申请
US20150018404A1 DOUBLE-STRANDED OLIGONUCLEOTIDE COMPOUNDS FOR TREATING HEARING AND BALANCE DISORDERS
审中-公开
用于治疗听觉和平衡障碍的双链寡核苷酸化合物
- 专利标题： DOUBLE-STRANDED OLIGONUCLEOTIDE COMPOUNDS FOR TREATING HEARING AND BALANCE DISORDERS
- 专利标题（中）： 用于治疗听觉和平衡障碍的双链寡核苷酸化合物
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申请号： US14235780申请日： 2012-08-03
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公开(公告)号： US20150018404A1公开(公告)日： 2015-01-15
- 发明人: Elena Feinstein , Sharon Avkin-Nachum , Igor Mett , Hagar Kalinski
- 申请人： Elena Feinstein , Sharon Avkin-Nachum , Igor Mett , Hagar Kalinski
- 申请人地址： US CA Fremont
- 专利权人： QUARK PHARMACEUTICALS, INC.
- 当前专利权人： QUARK PHARMACEUTICALS, INC.
- 当前专利权人地址： US CA Fremont
- 国际申请： PCT/US12/49616 WO 20120803
- 主分类号： C12N15/113
- IPC分类号： C12N15/113
摘要：
The present application relates to double stranded nucleic acid compounds, compositions comprising same and methods of use thereof for the treatment of hearing loss in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA molecules which inhibit expression of a gene expressed selected from the group consisting of HES1, HES5, HEY1, HEY2, ID1, ID2, ID3, CDKN1B, and NOTCH1.
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