A simulation environment is provided for running a process simulation used to validate an industrial control program. The simulation environment exposes the I/O module configurations defined in the control program and retrieves module configuration information therefrom. This I/O module configuration information is combined with generic, module-specific I/O module profiles to create a pool of available controller I/O points, which can be selectively associated with I/O points in the simulation to create an I/O point mapping. During control program validation, simulated I/O data is exchanged between the process simulation and the I/O module instances in the controller in accordance with the I/O point mapping. A variation of these techniques for use with cloud-based emulations is also described.