发明申请
- 专利标题： ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40L
- 专利标题（中）： 抗体CD40L的抗体多肽
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申请号： US14510474申请日： 2014-10-09
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公开(公告)号： US20150023976A1公开(公告)日： 2015-01-22
- 发明人: Steven G. NADLER , James K. TAMURA , Laura PRICE , Robert P. REHFUSS , Suzanne J. SUCHARD , Anish SURI , James William BRYSON , Aaron YAMNIUK , Steven GRANT , Olga IGNATOVICH , Philip DREW
- 申请人： BRISTOL-MYERS SQUIBB COMPANY , DOMANTIS LIMITED
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY,DOMANTIS LIMITED
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY,DOMANTIS LIMITED
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K45/06 ; A61K39/395 ; C07K16/46 ; C07K16/18
摘要：
Antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The antibody polypeptides are useful in the treatment of diseases involving CD40L activation, such as graft-related diseases and autoimmune diseases. The antibody polypeptides may be domain antibodies (dAbs) comprising a single VH or VK domain. The half-life of the antibody polypeptides may be increased by modifying the antibody polypeptides to be dual specific reagents that can also bind human serum albumin (HSA) or another antigen.
公开/授权文献
- US09228018B2 Antibody polypeptides that antagonize CD40L 公开/授权日：2016-01-05
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