发明申请
US20150025088A1 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS
审中-公开
用于治疗CNS疾病的6-环丙基 - 吡唑并嘧啶酮
- 专利标题: 6-CYCLOALKYL-PYRAZOLOPYRIMIDINONES FOR THE TREATMENT OF CNS DISORDERS
- 专利标题(中): 用于治疗CNS疾病的6-环丙基 - 吡唑并嘧啶酮
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申请号: US14511238申请日: 2014-10-10
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公开(公告)号: US20150025088A1公开(公告)日: 2015-01-22
- 发明人: Niklas HEINE , Christian EICKMEIER , Marco FERRERA , Riccardo GIOVANNINI , Holger ROSENBROCK , Gerhard SCHAENZLE
- 申请人: Niklas HEINE , Christian EICKMEIER , Marco FERRERA , Riccardo GIOVANNINI , Holger ROSENBROCK , Gerhard SCHAENZLE
- 申请人地址: DE Ingelheim am Rhein
- 专利权人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址: DE Ingelheim am Rhein
- 优先权: EP10172597.6 20100812; EP11154397.1 20110214
- 主分类号: C07D487/04
- IPC分类号: C07D487/04
摘要:
The invention relates to novel 6-Cycloalkyl-pyrazolopyrimidinones according to formula (I). wherein R1 is a 5 or 6 membered aromatic heteroaryl-group, R2 is an optional substituent, D is optionally substituted cyclopentyl, cyclohexyl, tetrahydrofuranyl, tetrahydropyranyl or 2-, 3- or 4-pyridyl, m=1 or 2 and n is 0, 1 or 2.The new compounds are for use as the active entity of medicaments or for the manufacture of medicaments respectively, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. Such conditions may for example be associated with Alzheimer's disease, schizophrenia and other diseases. The new compounds are also for example for the manufacture of medicaments and/or for use in the treatment of these diseases, in particular for cognitive impairment associated with such disease. The compounds of the invention show PDE9 inhibiting properties.
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