发明申请
US20150038460A1 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor
审中-公开
6,5-杂环炔丙醇化合物及其用途
- 专利标题: 6,5-Heterocyclic Propargylic Alcohol Compounds and Uses Therefor
- 专利标题(中): 6,5-杂环炔丙醇化合物及其用途
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申请号: US14515742申请日: 2014-10-16
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公开(公告)号: US20150038460A1公开(公告)日: 2015-02-05
- 发明人: Steven Staben , Jianwen Feng , Pui Leng Loke , Christian A.G.N. Montalbetti
- 申请人: Genentech, Inc.
- 申请人地址: US CA South San Francisco
- 专利权人: Genentech, Inc.
- 当前专利权人: Genentech, Inc.
- 当前专利权人地址: US CA South San Francisco
- 主分类号: C07F7/08
- IPC分类号: C07F7/08 ; C07D491/107 ; C07D403/14 ; C07D405/14 ; C07D413/14 ; C07D403/04 ; C07D487/04 ; C07D491/08 ; C07D401/14 ; C07D417/14
摘要:
The invention relates to novel compounds of Formula I: wherein A, Y, R1, R2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.