发明申请
US20150038490A1 SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
审中-公开
用于治疗阿尔茨海默病的螺旋罗哌啶β-分泌酶抑制剂
- 专利标题： SPIROPYRROLIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
- 专利标题（中）： 用于治疗阿尔茨海默病的螺旋罗哌啶β-分泌酶抑制剂
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申请号： US14518825申请日： 2014-10-20
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公开(公告)号： US20150038490A1公开(公告)日： 2015-02-05
- 发明人: Kun Liu , Shawn J. Stachel , Craig A. Coburn , Thomas G. Steele , Richard Soll , Hao Wu , Xuanjin Peng , Yaxian Cai , Xiaoxiang Du , Jian Li
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; C07D513/10 ; C07D495/10 ; C07D491/107 ; C07D471/10
摘要：
The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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