发明申请
- 专利标题： Thiazolopyrimidine Modulators as Immunosuppressive Agents
- 专利标题（中）： 噻唑并嘧啶调节剂作为免疫抑制剂
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申请号： US14518480申请日： 2014-10-20
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公开(公告)号： US20150038494A1公开(公告)日： 2015-02-05
- 发明人: Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
- 申请人： Piet Herdewijn , Steven De Jonghe , Ling-Jie Gao , Mi-Yeon Jang , Bart Vanderhoydonck , Mark Jozef Albert Waer , Yuan Lin , Jean Ferdinand Herman , Thierry Andre Michel Louat
- 申请人地址： BE Leuven
- 专利权人： Katholieke Universiteit Leuven, K.U.Leuven R&D
- 当前专利权人： Katholieke Universiteit Leuven, K.U.Leuven R&D
- 当前专利权人地址： BE Leuven
- 优先权： GB0904353.0 20090313; GB0904373.8 20090313; GB0911022.2 20090626
- 主分类号： C07D473/32
- IPC分类号： C07D473/32 ; A61K31/5513 ; C07D473/18 ; A61K31/5377 ; A61K31/517 ; A61K45/06
摘要：
The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1. The present invention also relates to a method for their preparation, as well as to pharmaceutical compositions thereof. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of disorders and pathologic conditions such as, but not limited to, immune and auto-immune disorders, organ and cells transplant rejections.
公开/授权文献
- US09221822B2 Thiazolopyrimidine modulators as immunosuppressive agents 公开/授权日：2015-12-29
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