A driving method of multi-common electrodes and a display device are provided. The driving method includes following steps: providing a plurality of common voltages, in which the common voltages include a first common voltage and a second common voltage, and the first common voltage is different from the second common voltage. During a first period, the first common voltage is set to a first voltage level to drive a first common electrode of a first pixel region in the display panel, and the second common voltage is set to a third voltage level to drive a second common electrode of a second pixel region in the display panel. During a second period, the first common voltage is set to a second voltage level to drive the first common electrode, and the second common voltage is set to a fourth voltage level to drive the second common electrode.