发明申请
US20150044255A1 INFECTIOUS cDNA CLONE OF NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND USES THEREOF
审中-公开
感染性cDNA克隆北美生殖和呼吸道综合征(PRRS)病毒及其用途
- 专利标题: INFECTIOUS cDNA CLONE OF NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND USES THEREOF
- 专利标题(中): 感染性cDNA克隆北美生殖和呼吸道综合征(PRRS)病毒及其用途
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申请号: US14521923申请日: 2014-10-23
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公开(公告)号: US20150044255A1公开(公告)日: 2015-02-12
- 发明人: Jay Gregory CALVERT , Michael G. Sheppard , Siao-Kun W. Welch , Raymond R. R. Rowland , Dal-Young Kim
- 申请人: Zoetis LLC
- 主分类号: C12N7/00
- IPC分类号: C12N7/00
摘要:
The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope of North American PRRS virus. The invention also provides vaccines comprising genetically modified North American PRRS virus, RNA molecules, plasmids and viral vectors comprising the isolated polynucleotide molecules. Also provided are isolated polynucleotide molecules further comprising at least one nucleotide sequence that encodes a detectable heterologous antigenic epitope, and vaccines comprising North American PRRS virus, RNA molecules, plasmids and viral vectors comprising such isolated polynucleotide molecules.