发明申请
US20150044670A1 PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE ALTERATIONS
审中-公开
ERG基因表达中的前列腺癌特异性改变和基于这些改变的检测和治疗方法
- 专利标题： PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE ALTERATIONS
- 专利标题（中）： ERG基因表达中的前列腺癌特异性改变和基于这些改变的检测和治疗方法
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申请号： US13974007申请日： 2013-08-22
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公开(公告)号： US20150044670A1公开(公告)日： 2015-02-12
- 发明人: Shiv Srivastava , Albert Dobi , Taduru Sreenath , Gyorgy Petrovics , Chen Sun
- 申请人： The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
- 申请人地址： US MD Bethesda
- 专利权人： The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
- 当前专利权人： The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.
- 当前专利权人地址： US MD Bethesda
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The disclosure describes alterations in ERG gene expression. ERG isoforms and promoter sequence of the ERG gene that are involved in, or associated with, prostate cancer are provided. The disclosure further provides therapeutic compositions and methods of detecting, diagnosing, prognosing, and treating prostate cancer, including biomarkers for detecting the expression of two or more of the following genes: PSA/KLK3, PMEPA1, NKX3.1, ODC1, AMD1, and ERG.
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