- 专利标题： INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME
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申请号： US14226615申请日： 2014-03-26
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公开(公告)号： US20150065508A1公开(公告)日： 2015-03-05
- 发明人: R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
- 申请人： R. Scott Bitner , Kaitlin E. Browman , Michael E. Brune , Steven Fung , Peer B. Jacobson , Lynne E. Rueter , Marina I. Strakhova , Jiahong Wang , Jyoti R. Patel , Qi Shuai , James T. Link , Jeffrey J. Rohde , Jurgen Dinges , Bryan K. Sorensen , Martin Winn , Hong Yong , Vince S. Yeh
- 申请人地址： US IL North Chicago
- 专利权人： ABBVIE INC.
- 当前专利权人： ABBVIE INC.
- 当前专利权人地址： US IL North Chicago
- 主分类号： C07C235/14
- IPC分类号： C07C235/14 ; C07C235/22 ; C07C271/28 ; C07D295/088 ; C07D207/48 ; C07D257/04 ; C07D401/04 ; C07D261/08 ; C07C237/24 ; C07C311/46
摘要：
The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.