This disclosure relates to optimizing power consumption for cellular communication based on transport block size in combination with channel condition measurements via power amplifier biasing. According to one embodiment, an indication of a transport block size to be used for uplink communication with a base station may be received. It may be determined that the transport block size provides more robust communication characteristics than required for current channel conditions. A power amplifier (PA) bias current for uplink communication with the cellular base station may be selected based at least in part on determining that the transport block size provides more robust communication characteristics than required for the current channel conditions. In particular, PA bias current selection may be biased to reduce power consumption at a cost of greater non-linearity based on the transport block size providing more robust communication characteristics than required for the current channel conditions.