发明申请
US20150087609A1 CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE
有权
细胞毒素递送分子靶向HIV（CDM-HS），抗人类免疫缺陷病毒的细胞毒活性及其使用方法
- 专利标题： CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE
- 专利标题（中）： 细胞毒素递送分子靶向HIV（CDM-HS），抗人类免疫缺陷病毒的细胞毒活性及其使用方法
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申请号： US14396956申请日： 2013-03-15
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公开(公告)号： US20150087609A1公开(公告)日： 2015-03-26
- 发明人: David Spiegel , Christopher Parker
- 申请人： YALE UNIVERSITY
- 国际申请： PCT/US13/32044 WO 20130315
- 主分类号： C07H15/26
- IPC分类号： C07H15/26 ; A61K45/06 ; A61K31/706
摘要：
The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.