Invention Application
US20150087657A1 MULTICOMPONENT CRYSTALLINE SYSTEM OF VORICONAZOLE WITH FUMARIC ACID
审中-公开
富马酸与富马酸的多元结晶体系
- Patent Title: MULTICOMPONENT CRYSTALLINE SYSTEM OF VORICONAZOLE WITH FUMARIC ACID
- Patent Title (中): 富马酸与富马酸的多元结晶体系
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Application No.: US14360799Application Date: 2012-12-03
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Publication No.: US20150087657A1Publication Date: 2015-03-26
- Inventor: Andreas Hafner , Tobias Hintermann , Fritz Blatter , Eva Roedel
- Applicant: BASF SE
- Applicant Address: DE Ludwigshafen
- Assignee: BASF SE
- Current Assignee: BASF SE
- Current Assignee Address: DE Ludwigshafen
- Priority: EP11192058.3 20111206
- International Application: PCT/IB12/56907 WO 20121203
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/194
Abstract:
A novel solid form of Voriconazole comprises the active ingredient (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol and fumaric acid. The solid composition comprising the two components shows improved properties such as water solubility, crystallization behavior and stability.
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