发明申请
- 专利标题: NON-AQUEOUS TAXANE FORMULATIONS AND METHODS OF USING THE SAME
- 专利标题(中): 非水性紫杉醇配方及其使用方法
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申请号: US14564384申请日: 2014-12-09
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公开(公告)号: US20150094361A1公开(公告)日: 2015-04-02
- 发明人: Kiichiro Nabeta
- 申请人: Teikoku Pharma USA, Inc.
- 申请人地址: US CA San Jose
- 专利权人: Teikoku Pharma USA, Inc,
- 当前专利权人: Teikoku Pharma USA, Inc,
- 当前专利权人地址: US CA San Jose
- 主分类号: A61K31/337
- IPC分类号: A61K31/337 ; A61K47/12 ; A61K47/26 ; A61K47/10 ; A61K47/44 ; A61K47/14
摘要:
Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.
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