An embodiment of the invention provides a patch for bio-electrical signal processing. The patch for bio-electrical signal processing includes a patch main body, a set of electrodes, and a lead signal generator. The patch main body has a folded state and an unfolded state. In each of the folded state and the unfolded state the patch main body is configured to be adhered to a living subject. The set of electrodes is disposed on the patch main body, and is configured to collect a set of skin voltages from the living subject. The lead signal generator is coupled to the set of electrodes, housed in the patch main body, and configured to receive the set of skin voltages from the set of electrodes and to generate a set of lead signals.