Systems and methods for uniformly interleaving memory accesses across physical channels of a memory space with a non-uniform storage capacity across the physical channels are disclosed. An interleaver is arranged in communication with one or more processors and a system memory. The interleaver identifies locations in a memory space supported by the memory channels and is responsive to logic that defines virtual sectors having a desired storage capacity. The interleaver accesses the asymmetric storage capacity uniformly across the virtual sectors in response to requests to access the memory space.