发明申请
- 专利标题： METHODS FOR MODULATING KALLIKREIN (KLKB1) EXPRESSION
- 专利标题（中）： 调整KALLIKREIN（KLKB1）表达的方法
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申请号： US14407816申请日： 2013-06-17
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公开(公告)号： US20150141497A1公开(公告)日： 2015-05-21
- 发明人: Edward Feener , Allen Clermont
- 申请人： Joslin Diabetes Center, Inc.
- 申请人地址： US MA Boston
- 专利权人： Joslin Diabetes Center, Inc.
- 当前专利权人： Joslin Diabetes Center, Inc.
- 当前专利权人地址： US MA Boston
- 国际申请： PCT/US2013/046147 WO 20130617
- 主分类号： A61K48/00
- IPC分类号： A61K48/00
摘要：
Disclosed herein are methods for decreasing kallikrein and treating, preventing, or ameliorating metabolic conditions in an individual in need thereof. Examples of disease conditions that can be treated, prevented, or ameliorated with the administration of antisense compounds targeted to kallikrein include obesity and diabetes. Methods for inhibiting kallikrein can also be used as a prophylactic treatment to prevent individuals at risk for developing a metabolic condition.
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