发明申请
US20150150951A1 PHARMACEUTICAL COMPOSITION COMPRISING BEE VENOM-PHOSPHOLIPASE A2 (BV-PLA2) FOR TREATING OR PREVENTING DISEASES RELATED TO DEGRADATION OF ABNORMAL REGULATORY T CELL ACTIVITY
有权
用于治疗或预防与异常调节性T细胞活性降解有关的疾病的BEE体细胞磷酸酶A2（BV-PLA2）的药物组合物
- 专利标题： PHARMACEUTICAL COMPOSITION COMPRISING BEE VENOM-PHOSPHOLIPASE A2 (BV-PLA2) FOR TREATING OR PREVENTING DISEASES RELATED TO DEGRADATION OF ABNORMAL REGULATORY T CELL ACTIVITY
- 专利标题（中）： 用于治疗或预防与异常调节性T细胞活性降解有关的疾病的BEE体细胞磷酸酶A2（BV-PLA2）的药物组合物
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申请号： US14381095申请日： 2012-06-04
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公开(公告)号： US20150150951A1公开(公告)日： 2015-06-04
- 发明人: Hyun Su Bae , Hyo Jung Lee , Gi Hyun Lee , Hyun Seong Kim , Soo Jin Park , Eun Sook Chung , Tae Won Choi
- 申请人： Hyun Su Bae , Hyo Jung Lee , Gi Hyun Lee , Hyun Seong Kim , Soo Jin Park , Eun Sook Chung , Tae Won Choi
- 优先权： KR10-2012-0019925 20120227
- 国际申请： PCT/KR2012/004394 WO 20120604
- 主分类号： A61K38/46
- IPC分类号： A61K38/46
摘要：
The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity comprising a polypeptide comprising a bee venom-PLA2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase A2 of the present invention activates a regulatory T cell and suppress a differentiation of Th1/Th7. Therefore, the present polypeptide can be used as a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory T cell activity, i.e. autoimmune diseases, allergic diseases, or neurodegenerative diseases.
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