发明申请
- 专利标题： TNF -Alpha Modulating Benzimidazoles
- 专利标题（中）： TNF-α调节苯并咪唑
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申请号： US14406848申请日： 2013-06-11
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公开(公告)号： US20150152065A1公开(公告)日： 2015-06-04
- 发明人: Daniel Christopher Brookings , Mark Daniel Calmiano , Ellen Olivia Gallimore , Helen Tracey Horsley , Martin Clive Hutchings , James Andrew Johnson , Boris Kroeplien , Fabien Claude Lecomte , Martin Alexander Lowe , Timothy John Norman , John Robert Porter , Joanna Rachel Quincey , James Thomas Reuberson , Matthew Duncan Selby , Michael Alan Shaw , Zhaoning Zhu , Anne Marie Foley
- 申请人： UCB Biopharma SPRL
- 优先权： GB1210233.1 20120611; GB1221983.8 20121206
- 国际申请： PCT/EP2013/062062 WO 20130611
- 主分类号： C07D235/12
- IPC分类号： C07D235/12 ; C07D401/04 ; A61K31/4439 ; A61K31/454 ; C07D405/06 ; A61K31/4192 ; C07D403/04 ; A61K31/4709 ; A61K31/4725 ; A61K31/444 ; C07D401/14 ; A61K31/5377 ; A61K31/541 ; A61K31/551 ; C07D491/107 ; A61K31/506 ; A61K31/4184
摘要：
A series of benzimidazole derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
公开/授权文献
- US09550737B2 TNF -α modulating benzimidazoles 公开/授权日：2017-01-24
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