发明申请
- 专利标题： Synthetic Oligosaccharides for P. Aeruginosa Vaccine
- 专利标题（中）： 铜绿假单胞菌疫苗的合成低聚糖
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申请号： US14414971申请日： 2013-07-03
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公开(公告)号： US20150152129A1公开(公告)日： 2015-06-04
- 发明人: A. Stewart Campbell , Obadiah J. Plante
- 申请人： SynGlyco, Inc.
- 国际申请： PCT/US13/49203 WO 20130703
- 主分类号： C07H15/12
- IPC分类号： C07H15/12 ; G01N33/569 ; C07K16/12 ; A61K47/48 ; A61K39/104 ; A61K39/39
摘要：
The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P. aeruginosa serotype-specific oligosaccharide antigens or various core P. aeruginosa oligosaccharide structures or motifs. The invention further provides P. aeruginosa LOS-based immunogenic and immunoprotective compositions and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by P. aeruginosa.