- 专利标题: BASE-BY-BASE RATCHETING OF DNA/RNA IN A Y-SHAPED NANOCHANNEL
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申请号: US14615891申请日: 2015-02-06
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公开(公告)号: US20150153309A1公开(公告)日: 2015-06-04
- 发明人: Binquan Luan , Ruhong Zhou
- 申请人: International Business Machines Corporation
- 主分类号: G01N27/447
- IPC分类号: G01N27/447 ; G01N27/453
摘要:
A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.
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