发明申请
- 专利标题： NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
- 专利标题（中）： 神经性STEROIDS，组合物及其用途
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申请号： US14343603申请日： 2012-09-07
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公开(公告)号： US20150158903A1公开(公告)日： 2015-06-11
- 发明人: Ravindra B. Upasani , Boyd L. Harrison , Benny C. Askew, Jr. , Jean-Cosme Dodart , Francesco G. Salituro , Albert J. Robichaud
- 申请人： Ravindra B. Upasani , Boyd L. Harrison , Benny C. Askew, Jr. , Jean-Cosme Dodart , Francesco G. Salituro , Albert J. Robichaud
- 申请人地址： US MA Cambridge
- 专利权人： SAGE THERAPEUTICS, INC.
- 当前专利权人： SAGE THERAPEUTICS, INC.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2012/054261 WO 20120907
- 主分类号： C07J41/00
- IPC分类号： C07J41/00 ; C07J1/00 ; C07J3/00 ; C07J9/00
摘要：
Compounds are provided according to Formula (I) and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v), and wherein L1, L2, L3, X1, X2, Y, Rz4, Rz5, Rz6, n, R1, R2, R3a, R3b, R4a, R4b, R6a, R6b, R7a, R7b, R11a, R11b, R14, R17, R19, R20, R23a, R23b, and R24 are as defined herein, and pharmaceutical compositions thereof. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions in mammals.
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