The invention relates to a device for applying a needle array (1) to biological tissue (2), comprising a needle array holder (6) carrying the needle array (1), a pre-tensioning geometry (3) and an actuating element (4), wherein the actuating element (4) is so configured that, during its actuation, in a first step it transfers the pre-tensioning geometry (3) into a pre-tensioning position on the biological tissue (2) while pre-tensioning the biological tissue, and in a second step it transfers the needle array (1) into an application position on the biological tissue (2), while in this respect the pre-tensioning geometry (3) is held in the pre-tensioning position by the actuating element (4).