Invention Application
US20150167004A1 OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES
审中-公开
DNA甲基衍生物的寡核苷酸抑制剂及其在治疗疾病中的应用
- Patent Title: OLIGONUCLEOTIDE INHIBITORS OF DNA METHYLTRANSFERASES AND THEIR USE IN TREATING DISEASES
- Patent Title (中): DNA甲基衍生物的寡核苷酸抑制剂及其在治疗疾病中的应用
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Application No.: US14413004Application Date: 2013-07-09
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Publication No.: US20150167004A1Publication Date: 2015-06-18
- Inventor: Andrew Z. Sledziewski , Theodore Devos , Ryszard Kole
- Applicant: METHEOR THERAPEUTICS CORPORATION
- International Application: PCT/US13/49624 WO 20130709
- Main IPC: C12N15/113
- IPC: C12N15/113
Abstract:
Modified oligonucleotides comprising CpG sites, wherein the cytosine is replaced by cytosine analogs are provided as well as methods of making the oligonucleotides and their use in inhibiting DNA Methyltransferase, inhibiting or reversing methylation of genes and in treating cancer, tumorigenesis and hyper-proliferative disorders.
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