Examples of a system and method for adaptively tuning a radio frequency (RF) front-end are generally described herein. In some examples, the frequency of a transmit signal of RF front-end circuitry is swept in at least a part of the RF transmit band. RF power in a receiver is detected as a function of the RF frequency of the transmit signal to determine a location of at least one tunable notch or other band stop element in the frequency domain. Information from the detected RF power is determined as a function of the RF frequency of the transmit signal. The RF front-end circuitry is adjusted to a selected frequency response using the determined information.