- 专利标题： COMPOSITIONS AND METHODS FOR TREATMENT
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申请号： US14610370申请日： 2015-01-30
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公开(公告)号： US20150175579A1公开(公告)日： 2015-06-25
- 发明人: Thomas Gadek , John Burnier
- 申请人： SARCODE BIOSCIENCE INC.
- 申请人地址： US CA BRISBANE
- 专利权人： SARCODE BIOSCIENCE INC.
- 当前专利权人： SARCODE BIOSCIENCE INC.
- 当前专利权人地址： US CA BRISBANE
- 主分类号： C07D405/06
- IPC分类号： C07D405/06
摘要：
The present invention provides compounds and methods for the treatment of LFA-1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patient is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.
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