The present disclosure provides a system and method for repairing poor display in a liquid crystal display panel. The system comprises: an image acquisition device for acquiring image data of the liquid crystal display panel containing poor display areas; a lossless compression module for calculating difference values between the acquired image data to perform lossless compression; a storage for storing data after the lossless compression; and a Mura repair module for decompressing the data in the storage, and repairing Mura of the decompressed original image data to generate information feed to the liquid crystal display panel. In the present invention, the acquired image data are stored in the storage, after being subjected to the lossless compression/decompression, and goes through the Mura repair, and then is output to the panel, such that both the capacity of the storage and the cost can be reduced without degrading the effect of De-Mura processing.