发明申请
- 专利标题： SELECTIVE EFFLUX INHIBITORS AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT
- 专利标题（中）： 选择性抑制剂和相关药物组合物和治疗方法
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申请号： US14587925申请日： 2014-12-31
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公开(公告)号： US20150197526A1公开(公告)日： 2015-07-16
- 发明人: Richard Smith Larson , Larry A. Sklar , Bruce S. Edwards , Juan Jacob Strouse , Irena Ivnitski-Steele , Hydya M. Khawaja , Jerec Warren Ricci , Jeffrey Aube , Jennifer Elizabeth Golden , Tuanli Yao , Warren S. Weiner , Chad E. Schroeder
- 申请人： STC.UNM , UNIVERSITY OF KANSAS
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/4745 ; A61K45/06 ; A61K31/519
摘要：
The present invention provides novel compounds which inhibit cancer-associated transporter proteins, methods of treating or preventing the onset of a cancer-associated transporter protein-mediated disease by administering such compounds, and pharmaceutical compositions comprising such compounds. In one embodiment, the invention provides novel pyrazolo[1,5-a]pyrimidine efflux inhibitors that are selective toward ABCG2 over ABCB1.