Invention Application
- Patent Title: STABILISED PROTEINS FOR IMMUNISING AGAINST STAPHYLOCOCCUS AUREUS
- Patent Title (中): 用于免疫斑马鱼的稳定蛋白
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Application No.: US14420229Application Date: 2013-08-29
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Publication No.: US20150202277A1Publication Date: 2015-07-23
- Inventor: Fabio Bagnoli , Simone Bufali , Simona Cianetti , Anna Coslovi , Guido Grandi , Mikkel Nissum , Michele Pallaoro , Silvana Savino , Michele Sotgiu
- Applicant: NOVARTIS AG
- International Application: PCT/EP2013/067855 WO 20130829
- Main IPC: A61K39/085
- IPC: A61K39/085 ; A61K39/39
Abstract:
Elimination of disulphide bond formation of cysteine-containing S.aureus antigens enhances antigen stability. The invention provides a composition comprising variant forms of cysteine-containing S.aureus antigen with a point mutation that replaces, deletes or modifies the cysteine residue.
Information query
