发明申请
US20150203477A1 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
有权
用于激活未经修饰的蛋白质应答的化合物的化合物和方法
- 专利标题： COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
- 专利标题（中）： 用于激活未经修饰的蛋白质应答的化合物的化合物和方法
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申请号： US14408736申请日： 2013-06-18
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公开(公告)号： US20150203477A1公开(公告)日： 2015-07-23
- 发明人: Jennifer E. Golden , Jeffrey Aube , Daniel P. Flaherty , Andrew M. Fribley , Randal J. Kaufman , Thomas D.Y. Chung , Anthony B. Pinkerton , Michael Pablo Hedrick
- 申请人： University of Kansas , The Regents of the University of Michigan , Wayne State University , Sanford-Burnham Medical Research Institute
- 国际申请： PCT/US13/46290 WO 20130618
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; C07C303/36 ; A61K45/06 ; A61K31/5377 ; A61K31/496 ; C07D307/71 ; A61K31/4525
摘要：
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
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