Invention Application
US20150203477A1 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
有权
用于激活未经修饰的蛋白质应答的化合物的化合物和方法
- Patent Title: COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE
- Patent Title (中): 用于激活未经修饰的蛋白质应答的化合物的化合物和方法
-
Application No.: US14408736Application Date: 2013-06-18
-
Publication No.: US20150203477A1Publication Date: 2015-07-23
- Inventor: Jennifer E. Golden , Jeffrey Aube , Daniel P. Flaherty , Andrew M. Fribley , Randal J. Kaufman , Thomas D.Y. Chung , Anthony B. Pinkerton , Michael Pablo Hedrick
- Applicant: University of Kansas , The Regents of the University of Michigan , Wayne State University , Sanford-Burnham Medical Research Institute
- International Application: PCT/US13/46290 WO 20130618
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07C303/36 ; A61K45/06 ; A61K31/5377 ; A61K31/496 ; C07D307/71 ; A61K31/4525
Abstract:
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.
Public/Granted literature
- US09732067B2 Compounds and methods for activating the apoptotic arm of the unfolded protein response Public/Granted day:2017-08-15
Information query
