Invention Application
- Patent Title: NOVEL AZABENZIMIDAZOLE TETRAHYDROFURAN DERIVATIVES
- Patent Title (中): 新型AZABENZIMIDAZOLE四氢呋喃衍生物
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Application No.: US14419825Application Date: 2013-08-19
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Publication No.: US20150203487A1Publication Date: 2015-07-23
- Inventor: James M. Apgar , Tesfaye Biftu , Ping Chen , Danqing Feng , Jacqueline D. Hicks , Ahmet Kekec , Kenneth J. Leavitt , Bing Li , Iyassu Sebhat , Xiaoxia Qian , Lan Wei , Robert R. Wilkening , Zhicai Wu , Ashok Arasappan
- Applicant: Merck Sharp & Dohme Corp.
- International Application: PCT/US13/55531 WO 20130819
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/437 ; C07D519/00 ; C07C53/18 ; A61K31/4985 ; A61K31/5377 ; A61K31/496 ; A61K31/366 ; A61K31/397 ; A61K31/444 ; A61K31/19
Abstract:
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
Public/Granted literature
- US09868733B2 Azabenzimidazole tetrahydrofuran derivatives Public/Granted day:2018-01-16
Information query
