Some demonstrative embodiments include devices, systems and/or methods of configuring a radio transceiver. For example, some embodiment include a radio virtual machine (RVM) to configure a radio transceiver, the RVM including a radio processor to execute a first code configuring one or more transceiver functionalities independent of a configuration of the radio transceiver, and to generate a second code based on the configuration of the radio transceiver and the first code, wherein the second code is to be executed by the radio transceiver to configure the one or more transceiver functionalities for the radio transceiver.