The disclosure discloses a method and a device for processing and managing an establishment of an X2 connection. The method comprises: a home NodeB acquires the address of an adjacent NodeB corresponding to the home NodeB, wherein the address is for establishing an X2 connection between the home NodeB and the adjacent NodeB; and the home NodeB sends the acquired address to an X2 gateway. In the disclosure, the technical problem in the related art that the X2 connection between the home NodeB and the adjacent NodeB cannot be established because the X2 gateway cannot acquire the address of the adjacent NodeB of the home NodeB is solved, thus implementing the establishment of the X2 connection between the home NodeB and the adjacent NodeB.