Invention Application
- Patent Title: Method for Identifying Compounds of Therapeutic Interest
- Patent Title (中): 识别治疗兴趣化合物的方法
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Application No.: US14409424Application Date: 2013-06-28
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Publication No.: US20150219635A1Publication Date: 2015-08-06
- Inventor: Alastair David Griffiths Lawson , Alistair James Henry
- Applicant: UCB PHARMA S.A.
- International Application: PCT/EP2013/063747 WO 20130628
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G06F19/16

Abstract:
The present invention relates to an improved method for drug discovery. In particular the present invention provides a method of identifying compounds capable of binding to a functional conformational state of a protein of interest or protein fragment thereof, said method comprising the steps of: (a) Binding a function-modifying antibody to the target protein of interest or a fragment thereof to provide an antibody-constrained protein or fragment, wherein the antibody has binding kinetics with the protein or fragment which are such that it has a low dissociation rate constant, (b) Providing a test compound which has a low molecular weight, (c) Evaluating whether the test compound of step b) binds the antibody constrained protein or fragment, and (d) Select a compound from step c) based on the ability to bind to the protein or fragment thereof.
Public/Granted literature
- US10048253B2 Method for identifying compounds of therapeutic interest Public/Granted day:2018-08-14
Information query
IPC分类: