发明申请
US20150252034A1 BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
有权
在电压筛选的通道中具有选择性活性的苯并咪唑啉酮化合物
- 专利标题： BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS
- 专利标题（中）： 在电压筛选的通道中具有选择性活性的苯并咪唑啉酮化合物
-
申请号： US14437315申请日： 2013-10-23
-
公开(公告)号： US20150252034A1公开(公告)日： 2015-09-10
- 发明人: Joseph E. Pero , Hannah D.G.F. Lehman , Michael J. Kelly, III , Lianyun Zhao , Michael A. Rossi , Dansu Li , Kevin F. Gilbert , Scott Wolkenberg , James Mulhearn , Mark E. Layton , Pablo de Leon
- 申请人： Merck Sharp & Dohme Corp.
- 国际申请： PCT/US2013/066357 WO 20131023
- 主分类号： C07D413/14
- IPC分类号： C07D413/14 ; C07D413/12
摘要：
Disclosed are compounds of Formula A: Formula A, or a salt thereof, wherein “Het”, Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating neuropathic pain disorders using the same.
公开/授权文献
信息查询
