Invention Application
- Patent Title: SUBSTITUTED 1,5-BENZODIAZEPINONES COMPOUNDS
- Patent Title (中): 取代1,5-二苯并恶嗪化合物
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Application No.: US14429964Application Date: 2013-09-20
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Publication No.: US20150274679A1Publication Date: 2015-10-01
- Inventor: Patrice Gill , Claude A. Quesnelle , Mark G. Saulnier , Ashvinikumar V. Gavai
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- International Application: PCT/US13/60781 WO 20130920
- Main IPC: C07D243/14
- IPC: C07D243/14 ; C07D401/04 ; A61K45/06 ; A61K31/5513
Abstract:
Disclosed are compounds of Formula (I): wherein: R1 is CH2CH2CF3; R2 is CH2CH2CF3, CH2(cyclopropyl), or phenyl; R3 is H or CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.
Public/Granted literature
- US09187434B2 Substituted 1,5-benzodiazepinones compounds Public/Granted day:2015-11-17
Information query
