发明申请
US20150299125A1 PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS
审中-公开
PRODRUG BIPYRIDYLAMINOPYRIDINES作为SYK抑制剂
- 专利标题： PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS
- 专利标题（中）： PRODRUG BIPYRIDYLAMINOPYRIDINES作为SYK抑制剂
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申请号： US14440517申请日： 2013-11-04
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公开(公告)号： US20150299125A1公开(公告)日： 2015-10-22
- 发明人: Andrew M. Haidle , Brandon Cash , James P. Jewell , Kerrie Spencer , Michael D. Altman , Ryan D. Otte , Alan B. Northrup
- 申请人： Andrew M. HAIDLE , Brandon CASH , James P. JEWELL , Kerrie SPENCER , Michael D. ALTMAN , Ryan D. OTTE , Alan B. NORTHRUP , MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US13/68189 WO 20131104
- 主分类号： C07D213/74
- IPC分类号： C07D213/74 ; C07D401/14 ; C07D405/14
摘要：
The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3′-bipyridin-6′-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
公开/授权文献
- US1233835A Curtain-pole. 公开/授权日：1917-07-17