An active fuel pressure pulsation cancellation technique includes receiving, at a controller of an engine having a camshaft-driven fuel pump, an unfiltered fuel pressure signal indicative of a measured pressure of fuel in a fuel rail. The technique includes detecting, at the controller, fuel pressure pulsations in the fuel rail based on the unfiltered fuel pressure signal. The technique includes generating, at the controller, a cancellation signal based on an opposite polarity of the fuel pressure pulsations. The technique also includes controlling, by the controller, an actuator associated with the fuel rail using the cancellation signal to cause the actuator to generate liquid-borne cancellation pulsations that cancel the fuel pressure pulsations in the fuel rail.