发明申请
US20150316565A1 Methodologies and Reagents for Detecting Fibrinolysis and Hyperfibrinolysis
有权
用于检测纤维蛋白溶解和超纤维蛋白溶解的方法和试剂
- 专利标题： Methodologies and Reagents for Detecting Fibrinolysis and Hyperfibrinolysis
- 专利标题（中）： 用于检测纤维蛋白溶解和超纤维蛋白溶解的方法和试剂
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申请号： US14270269申请日： 2014-05-05
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公开(公告)号： US20150316565A1公开(公告)日： 2015-11-05
- 发明人: Michael P. Chapman , Ernest E. Moore , Katherine M. Norem
- 申请人： Haemonetics Corporation , The Regents of the University of Colorado
- 申请人地址： US MA Braintree US CO Denver
- 专利权人： Haemonetics Corporation,The Regents of the University of Colorado
- 当前专利权人： Haemonetics Corporation,The Regents of the University of Colorado
- 当前专利权人地址： US MA Braintree US CO Denver
- 主分类号： G01N33/86
- IPC分类号： G01N33/86
摘要：
In some embodiments, the invention provides methods for detecting fibrinolysis or hyperfibrinolysis in a blood sample from a patient. The method includes subjecting a first portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the absence of an inhibitor of fibrinolysis to obtain the coagulation characteristic of the first portion at the time point; and subjecting a second portion of the blood sample comprising reduced platelet function to viscoelastic analysis in the presence of an inhibitor of fibrinolysis to obtain a coagulation characteristic of the second portion at a time point; wherein a difference between the coagulation characteristic of the first portion and the coagulation characteristic of the second portion indicates fibrinolysis or hyperfibrinolysis in the blood sample.In some embodiments, the invention also provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.
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