发明申请
- 专利标题: TABLET QUICKLY DISINTEGRATING IN THE ORAL CAVITY AND METHOD FOR PRODUCING THE SAME
- 专利标题(中): 片剂快速消毒口腔及其生产方法
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申请号: US14806296申请日: 2015-07-22
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公开(公告)号: US20150320688A1公开(公告)日: 2015-11-12
- 发明人: Toru FUKUSHIMA , Takashi SHIMIZU , Teruko YOSHIDA
- 申请人: Sumitomo Dainippon Pharma Co., Ltd.
- 优先权: JP2008-155300 20080613
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; B29C43/00 ; A61K31/192 ; A61K31/198 ; A61K31/166
摘要:
The invention relates to a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient at a high content and a production method thereof. That is, the present invention provides a tablet which is rapidly disintegrated in an oral cavity containing an active ingredient in not less than 25% of the total weight, having a disintegration time of within 40 seconds and an absolute hardness of 1.8 N/mm2 or more, which is obtained by granulating a powder containing an active ingredient with a binding solution containing mannitol and corn-derived pregelatinized starch, mixing the resulting granules with at least one kind of a disintegrant selected from cornstarch, hydroxypropylstarch, carmellose and crospovidone, and compression molding the mixture.
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