发明申请
US20150320749A1 IMMEDIATE RELEASE 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide FORMULATION
有权
立即释放4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基] -N- [5-（4-甲基-1H-咪唑-1-基）-3-（三氟甲基）苯基 苯甲酰胺配方
![IMMEDIATE RELEASE 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide FORMULATION](/docs/US/2015-11-12/US20150320749A1/abs.jpg.600x600.jpg)
- 专利标题： IMMEDIATE RELEASE 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide FORMULATION
- 专利标题（中）： 立即释放4-甲基-3 - [[4-（3-吡啶基）-2-嘧啶基]氨基] -N- [5-（4-甲基-1H-咪唑-1-基）-3-（三氟甲基）苯基 苯甲酰胺配方
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申请号： US14273874申请日： 2014-05-09
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公开(公告)号： US20150320749A1公开(公告)日： 2015-11-12
- 发明人: Upkar Bhardwaj , Ann Reese Comfort , Ping Li , Shoufeng Li , Alexey Makarov , Mangesh Sadashiv Bordawekar
- 申请人： Upkar Bhardwaj , Ann Reese Comfort , Ping Li , Shoufeng Li , Alexey Makarov , Mangesh Sadashiv Bordawekar
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; A61K9/28
![IMMEDIATE RELEASE 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide FORMULATION](/abs-image/US/2015/11/12/US20150320749A1/abs.jpg.150x150.jpg)
摘要：
A solid dosage form of nilotinib is disclosed that comprises: (i) a core comprising 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1 H-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide or a pharmaceutically acceptable salt thereof and excipients; and (ii) at least one polymer, said polymer coating said core, wherein disintegration of said solid dosage form is delayed