发明申请
US20150329599A1 PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES
有权
具有重复性细菌类型（大）的蛋白质在LEPTOSPIRA物种中存在
- 专利标题： PROTEINS WITH REPETITIVE BACTERIAL-IG-LIKE (BIG) DOMAINS PRESENT IN LEPTOSPIRA SPECIES
- 专利标题（中）： 具有重复性细菌类型（大）的蛋白质在LEPTOSPIRA物种中存在
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申请号： US14819045申请日： 2015-08-05
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公开(公告)号： US20150329599A1公开(公告)日： 2015-11-19
- 发明人: Albert I. Ko , Mitermayer Galvao Reis , Julio Henrique Rosa Croda , Isadora Cristina Siqueira , David A. Haake , James Matsunaga , Lee W. Riley , Michele Barocchi , Tracy Ann Young
- 申请人： The United States Government represented by the Department of Veterans Affairs , The Regents of the University of California , Cornell Research Foundation, Inc. , Fundação Oswaldo Cruz - FIOCRUZ
- 专利权人： The United States Government represented by the Department of Veterans Affairs,The Regents of the University of California,Cornell Research Foundation, Inc.,Fundação Oswaldo Cruz - FIOCRUZ
- 当前专利权人： The United States Government represented by the Department of Veterans Affairs,The Regents of the University of California,Cornell Research Foundation, Inc.,Fundação Oswaldo Cruz - FIOCRUZ
- 主分类号： C07K14/20
- IPC分类号： C07K14/20
摘要：
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.